Differential Susceptibility – Are some brains more plastic than others?

Ever heard of the idea that for some illnesses and disorders to develop, you need to have an inherited risk factor plus environmental stress? It’s known commonly as the diathesis-stress model (diathesis basically means predisposition), and it’s a common explanation for a large range of phenomena, from schizophrenia to serial murder. Both diathesis and stress need to be present for the illness to arise.

This has been the prevailing view for some time, but a few researchers, such as Jay Belsky and Michael Pluess of Birkbeck university, are now making a slightly different case. They don’t say that the diathesis-stress model is incorrect, rather, that it is incomplete.

They have noted multiple instances in the existing research base in which the diathesis side of the model – for example the function of genes, or phenotypic characteristics – would be better explained as what they call ‘plasticity factors’, as opposed to ‘vulnerability factors’.

Is the diathesis-stress model incomplete?

Let’s look at the current viewpoint in a little more detail. Typically, certain people are thought to possess particular gene variants which make them more likely to develop a psychological condition, for example depression, when a certain conditions occur in their life. So, someone with a different allele (different versions of the same gene are known as ‘alleles’) could go through the same experiences, and not come out the other side depressed.

The new point of view would say that rather than having a risk for certain illnesses, these people may actually have a brain that is more responsive to the environment generally. If they did not go through a stressful period, but instead a supportive, nurturing one, they would be more likely to develop beneficial psychological characteristics – and again, people who had different versions of the gene could go through the same experiences and not come out the other side as well off.

This model is called ‘differential susceptibility’; people differ in their susceptibility to environmental influence. The implication is that some brains are more plastic than others, and are therefore more susceptible to both positive and negative effects of supportive and unsupportive environments.

Vulnerability or Plasticity?

Over the years a number of studies on temperament in children have been published which appeared to supported the diathesis-stress model. They generally show that differences in parenting style predict differences in self-control, externalising problems, and other aspects of difficult temperament. But the limitation of these studies is that they did not test for whether these same children would be more likely to receive benefits from different parenting styles. In other words, these studies were not designed to tell the difference between vulnerability and plasticity – only to detect vulnerability.

Chill out…

A number of other studies, however, have been designed in a way that gets around this problem, and many have supported the idea of general plasticity. To give an example, one study found that teenage boys with difficult temperament were the least likely to externalise problems after 6 months with sensitive, non-controlling mothers; but they were also the most likely to externalise problems after 6 months with insensitive, controlling mothers. Furthering the support for the theory, this pattern was not found in the teenagers who did not have a difficult temperament. (2)

Another study, this time with an experimental design, looked at mothers who were thought to be at risk of developing insecure children due to their own difficulties. These mothers were given an intervention in the form of a video feedback exercise, which successfully improved their parenting skills. Was the intervention successful in building a more secure attachment style from the infants? Yes it was, but only for those who had a high level of negative reactivity prior to the intervention. (3)

Genetic Markers of Differential Susceptibility


We’ve looked at a few studies which might demonstrate the effects of differential susceptibility in the ‘real world’. There is also some evidence looking into the effects of genes, and again Belsky and Pluess (1) argue that because previous research had been led by the diathesis-stress model, findings which might support differential susceptibility have tended to go overlooked.

If anything I’ve said up to now has been familiar to you, you might have heard of the 5-HTTLPR gene. It has had attention in the media and popular books (eg., The How of Happiness) for being the ‘depression gene’, in that people who have a specific variant of this gene, the so called ‘short allele’, are more susceptible to depression.

A number of studies have supported this finding, but there have been some results which suggest the pattern may not be so clear as yet. One study found, as predicted, that young adults with two short alleles had the most severe symptoms of depression when they had experienced problematic childhoods. However, when short allele children had experienced a supportive childhood, they actually showed the fewest symptoms of depression later in life. (4)

A warm and fuzzy conclusion?

Although the recent evidence for individual differences in plasticity is quite compelling, the authors are very tentative and cautious in their papers, which I suppose is necessary when you’re proposing something new. You don’t want to scare anyone off. So they are keen to point out that the evidence is not quite solid as yet, and there is more work to be done.

This line of work is only beginning, and there are many unknowns. Much the same as in priming research, the evidence of the effect is running a little ahead of the understanding of the mechanisms involved, and researchers are unclear on whether differential susceptibility stems mostly from ‘nature’ or ‘nurture’, or on the breadth of the phenomena that it applies to. Having said that, the idea that that the people most susceptible to negative symptoms and experiences might be the people most susceptible to positive symptoms and experiences, is quite a cheerful thought.


(1) Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135(6), 885-908

(2) van Aken, C., Junger, M., Verhoeven, M., van Aken, M., & Dekovi?, M. (2007). The interactive effects of temperament and maternal parenting on toddlers’ externalizing behaviours. Infant and Child Development, 16(5), 553-572.

(3) Klein Velderman, M., Bakermans-Kranenburg, M., Juffer, F., & van IJzendoorn, M. (2006). Effects of attachment-based interventions on maternal sensitivity and infant attachment: Differential susceptibility of highly reactive infants. Journal of Family Psychology, 20(2), 266-274.

(4) Taylor, S., Way, B., Welch, W., Hilmert, C., Lehman, B., & Eisenberger, N. (2006). Early Family Environment, Current Adversity, the Serotonin Transporter Promoter Polymorphism, and Depressive Symptomatology. Biological Psychiatry, 60(7), 671-676.


  • Hello fellow redditor! I enjoyed the well-constructed post. I think it’s pretty clear that ADHD and other temperamental disorders is a behavioral phenotype that is more than just a fluke, based on the preponderance within the human population. I believe there has to be advantages to such characteristics coming from some angle. I think, chiefly among those, the higher rate of autistic-spectrum disorders (ADHD, dyslexia, etc. included) among entrepreneurs is a good example.

    One question for you! (And hey, install subscribe-to-comments so it’s easier for me to see your reply!)

    “A number of other studies, however, have been designed in a way that gets around this problem, and many have supported the idea of general plasticity. To give an example, one study found that teenage boys with difficult temperament were the least likely to externalise problems after 6 months with sensitive, non-controlling mothers”

    Were these foster parents? I know that you cited (thank you) but I think this could’ve been more clear in your post.

    • Warren Davies says:

      Hello, welcome! That’s quite possibly true, there might be or have been some benefits to the kind of information-processing that goes along with ADHD etc. I’ll have to look into that one.

      Good question – no, they were biological. The mother-child pairings were observed during a short play activity (structured in the same way for each pairing), and these results were used to predict measures taken 6 months later.

  • webhotel says:

    The way you drawn the results on the basis of such volatile facts is really awesome, thanks for sharing the great piece of knowledge!

    • Warren Davies says:

      Thanks, but I’m really just summarising Belsky and Pleuss’s work and these aren’t my conclusions (this is way out of my little league!).

  • Dot says:

    Fascinating research with many ramifications! Thanks for posting it. Given the new info that some brains may be more plastic and therefore susceptible to environmental effects than others, my question for you is this:

    Can the brain retrain itself? For instance, if someone has ADHD and can compare herself with her siblings, who do not have the condition, will she be able to consciously retrain her brain through plasticity exercises, or is it too late?
    .-= Dot´s last blog ..Don’t Miss RehabRN’s Change of Shift Roundup =-.

    • Warren Davies says:

      Well, that’s the million dollar question, or one of them at least. Certainly the brain can retrain and alter itself in line with the experiences we’re having, but to what extent this can equate to changes in ADHD symptoms over time, I don’t know. I’m not very familiar with ADHD, so I wouldn’t feel right commenting on that.

  • kanishk says:

    I am student of biotechnology I aware about these all the things but
    Your post gives me new update and thanks for sharing great piece
    Of knowledge. first time visited your blog and would like to come again.
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  • are there really more illnesses now than there were 50 or 100 years ago..? im sure we invent half of them either because we are lazy or scientists just need something to do. talking to older generations about such things its easy to see why someone might think this! my grandpa always says ‘in their day’ they just got on with it. i read an article linking internet use with depression… maybe its true who knows.

    • Warren Davies says:

      There’s definitely the possibility that differences are being labelled as disorders a little over-zealously, but I think the deciding factor is whether they interfere with a person’s life. If they do in a severe way, there’s a case to be made to put some effort into researching the causes and treatments of it.

  • I dont think there are more illnesses now than there were 50 or 100 years ago, but just that we keep discovering them. New species are discovered every day and I’m sure the same thing applies to illnesses. Understanding the illnesses is positive though, it helps us empathise and support people suffering from them.

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